Jesse Weiland (Matt Dillon) is a contract killer for a ruthless criminal organization led by Lutin (Tom Berenger) who also dabbles in some safe-cracking action on the side. When he gets arrested by Louisiana detective Bud Carter (Willem Dafoe), he’s prepared to do the time. Lutin however isn’t so sure and takes measures to ensure Weiland’s silence. His actions backfire and make Weiland an adversary who teams up with Carter in order to take down the entire organization.

Duncan (Ken Marino) is a poor schmuck who gets the shit kicked out of him in life. His boss makes his life impossible, his girlfriend Sarah (Gillian Jacobs) is needy and his mom is not only meddling but she has a new boyfriend who’s about one third of her age. Plus he struggles with some daddy issues. As if all that isn’t bad enough just yet, he also suffers excruciating pains every time he has to go take a dump.